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	Test for Newborns Detects Blood Disorder Wed Dec 09, 2009 5:18 am

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DoctorNutopia

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Joined: 06 Nov 2009

Posts: 2743

Post subject: Test for Newborns Detects Blood Disorder

Test for Newborns Detects Blood Disorder

Dec. 8, 2009 -- An inexpensive new newborn screening method can detect a
rare blood disorder that affects the immune system and causes life-threatening
complications if left untreated.
A new study shows testing of newborn DNA extracted from dried blood spots on
newborn blood screening cards was able to identify infants with T-cell
lymphopenia, which is an abnormally low level of vital infection-fighting white
blood cells. Infants with T-cell lymphopenia may appear normal at birth and
have no family history of immune disorders.
"Consequently, many infants with severe T-cell deficiencies are not
identified until life-threatening infections occur," write researcher John M.
Routes, MD, of the Medical College of Wisconsin and Children's Research
Institute in Milwaukee, in The Journal of the American Medical
Association.
Researchers say this is an important issue because early diagnosis and
treatment of T-cell lymphopenia can dramatically improve the long-term health
of the child. In addition, some childhood vaccines given in early infancy may
cause serious infection in children with T-cell lymphopenia.
In the study, researchers looked at whether determining the number of T-cell
receptor excision circles (TREC) using DNA from dried blood spots on newborn
blood screening cards could detect the disorder in infants in a statewide
screening program.
Researchers screened 71,000 infants born in 2008 in Wisconsin using the TREC
method. Seventeen full-term infants had at least one abnormal TREC result, 11
of whom had samples further analyzed to detect the number of T cells. Eight of
those infants were diagnosed with T-cell lymphopenia.
The cost of the test was about $5.50, and researchers say the number of
cases detected by the newborn screening exceeds the required incidence of
disease to institute screening.
They say these results support state screening for T-cell lymphopenia,
although a formal cost-effectiveness analysis is needed.
http://www .webmd.com/baby/news/20091208/test-for-newborns-detects-blood-disorders?src=RSS_PUBLIC

	Test for Newborns Detects Blood Disorder Wed Dec 09, 2009 5:18 am

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