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Skin Cancer Drug Erivedge Approved Wed Feb 01, 2012 2:48 am
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Skin Cancer Drug Erivedge Approved


Jan. 31, 2012 -- The FDA has approved Erivedge, a once-daily pill that can shrink disfiguring or metastatic basal cell carcinoma (BCC) tumors.

BCC, the most common form of skin cancer, usually is curable. But in rare cases, the cancer spreads through the body or invades surrounding parts of the body.

These advanced, sometimes disfiguring cancers often cannot be completely eliminated with surgery or radiation.

But BCC cancer cells need a signal, dubbed Hedgehog, to grow. Erivedge inhibits this signal.

In a single clinical study that enrolled 96 patients with advanced or spreading BCC, Erivedge shrank the tumors in 30% of those with metastatic cancer and shrank or eliminated tumors in 43% of patients with locally advanced cancer.

That was enough for the FDA to approve Erivedge under its speediest form of review.

The approval comes with the FDA's "black box" warning -- it's most severe safety alert -- noting that the drug carries a risk of causing stillbirth or severe birth defects. It cannot be used by pregnant women. Men taking Erivedge must use condoms, even if they have had vasectomies, to avoid unintentionally contaminating their female partners with the drug.

The most common side effects observed in patients treated with Erivedge were muscle spasms, hair loss, weight loss, nausea, diarrhea, fatigue, distorted sense of taste, decreased appetite, constipation, vomiting, and loss of taste function in the tongue.

Erivedge will be available in the U.S. within two weeks. However, it will not be sold at retail pharmacies, but must be dispensed at "specialty pharmacies" where staff is trained to offer patient education.

Erivedge is made by Genentech, a Roche company. The firm says it soon will seek approval in the European Union.

http://www.webmd.com/cancer/news/20120131/skin-cancer-drug-erivedge-approved?src=RSS_PUBLIC
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Skin Cancer Drug Erivedge Approved Wed Feb 01, 2012 2:48 am
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