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Pill May Boost HDL 'Good' Cholesterol Tue Nov 15, 2011 9:25 pm
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Pill May Boost HDL 'Good' Cholesterol


Nov. 15, 2011 (Orlando, Fla.) -- Once again, an experimental pill that boosts levels of HDL "good" cholesterol has shown promising results in a mid-stage study.

In a three-month study of nearly 400 people, the drug evacetrapib raised HDL and lowered LDL, the so-called "bad cholesterol" -- both when given alone and with standard cholesterol-lowering statin drugs.

Importantly, evacetrapib did not routinely increase blood pressure or produce any of the other toxic effects that halted development of its predecessor, torcetrapib.

The big question, however, is whether raising levels of good cholesterol will prevent heart attacks, strokes, and deaths, says Robert Harrington, MD, of Duke University Medical Center in Durham, N.C. He was not involved with the study, but has consulted for the maker of another HDL-boosting drug.

More people have to be followed for longer periods of time to ensure the drug both prevents heart problems and is safe over the long term, he tells WebMD.

"With torcetrapib, we didn’t see the problem until thousands of patients were taking it for longer periods," Harrington says.

The study appears in the Nov. 16 issue of The Journal of the American Medical Association. It was released early online today to coincide with its presentation at the American Heart Association (AHA) Scientific Sessions.

http://www.webmd.com/cholesterol-management/news/20111114/pill-may-boost-hdl-good-cholesterol?src=RSS_PUBLIC
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Pill May Boost HDL 'Good' Cholesterol Tue Nov 15, 2011 9:25 pm
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