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New Oral RA Drug Works in Unique Way Fri Jun 03, 2011 11:19 pm
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New Oral RA Drug Works in Unique Way


May 26, 2011 -- An experimental drug called tofacitinib may help treat rheumatoid arthritis -- and it's taken as a pill, rather than as an injection or infusion.

In London, researchers reported results from a study in which rheumatoid arthritis (RA) patients took tofacitnib or a placebo. Tofacitinib improved symptoms better than the placebo and worked quickly in patients who had not responded to other medicines.

In the drug's study, side effects included infections, but most were mild, Kremer says. Four patients died during or after the trial, but the drug is not thought to be involved in most of those cases, and the researchers found the drug's safety profile to be "acceptable."

The results were presented at EULAR 2011, the Congress of the European League Against Rheumatism.

The new oral RA drug is in a class of drugs called JAK inhibitors. "It targets the disease in a unique manner," says researcher Joel Kremer, MD, the Pfaff Family Professor of Medicine and director of research at the Center for Rheumatology at Albany College in New York.

"It blocks molecules within the cell involved in signaling to promote inflammation," Kremer tells WebMD. "It works quickly and it's consistently effective." 

Besides tofacitinib, which is being developed by Pfizer, several other JAK inhibitor drugs are in development by competitors.

According to the Arthritis Foundation, about 1.3 million Americans have RA. It is an inflammatory arthritis in which the immune system attacks the body's own tissues, especially the membranes lining the joints. Stiffness, pain, and disability can result.

 

http://www.webmd.com/rheumatoid-arthritis/news/20110526/new-oral-ra-drug-works-unique-way?src=RSS_PUBLIC
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New Oral RA Drug Works in Unique Way Fri Jun 03, 2011 11:19 pm
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New Oral RA Drug Works in Unique Way




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