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New Genetic Clues to Ovarian Cancer Thu Jun 30, 2011 7:39 am
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New Genetic Clues to Ovarian Cancer


June 29, 2011 -- Multiple genetic mutations appear to be involved in the development of ovarian cancer, according to a new large-scale analysis of tumor samples.

Researchers from the Cancer Genome Atlas Research Network looked at 489 high-grade serous ovarian adenocarcinomas (HGS-OvCa). These are a kind of epithelial ovarian cancer, the most common kind.

Ovarian cancer is the fifth-leading cause of cancer death among U.S. women, the researchers write in the journal Nature.

Nearly 22,000 new cases were found in the U.S. in 2010, according to estimates. Nearly 14,000 U.S. women died from the cancer last year, the researchers report.

After analyzing the samples, the researchers found that mutations in a gene known as TP53 predominated. It was found in 96% of the tumor samples.

However, the researchers found mutations in nine other genes, including NF1, BRCA1 and BRCA2, RB1, and CDK12. BRCA1 and BRCA2 were mutated in 22% of the samples. The other seven mutated genes identified were only found in 2% to 6% of the samples.

''The mutation spectrum marks HGS-OvCa as completely distinct from other ovarian cancer histological subtypes," the researchers write.

http://www.webmd.com/ovarian-cancer/news/20110629/new-genetic-clues-to-ovarian-cancer?src=RSS_PUBLIC
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New Genetic Clues to Ovarian Cancer Thu Jun 30, 2011 7:39 am
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