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FDA: Some Asthma Drugs Riskier for Kids Than Adults Wed Oct 26, 2011 7:11 am
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FDA: Some Asthma Drugs Riskier for Kids Than Adults


Oct. 25, 2011 -- Children are more vulnerable than adults to rare but potentially life-threatening events associated with asthma drugs known as long-acting beta-agonists (LABAs), a new analysis from the FDA shows.

The analysis is published in Pediatrics.

Early last year, an FDA panel concluded that the single-agent LABA inhalers Serevent and Foradil should only be used in combination with an asthma controller (long-term maintenance drug), such as an inhaled corticosteroid, to reduce the risk for a severe, fatal asthma attack associated with LABAs.

LABAs help control and prevent airway spasms during asthma attacks. But they do not treat the inflammation that produces airway constriction, and that's where the corticosteroids help.

The agency also concluded that use of the widely prescribed combined LABA and inhaled corticosteroid products Advair and Symbicort should be restricted to patients whose asthma was not adequately controlled with other asthma controller drugs as a first option. The FDA also said that children and teens who require LABAs take only combination drugs containing both an inhaled corticosteroid and a LABA.

Ann W. McMahon, MD, of the FDA's office of pediatric therapeutics, says the new analysis does not change these recommendations.

http://www.webmd.com/asthma/news/20111025/fda-some-asthma-drugs-riskier-for-kids-than-adults?src=RSS_PUBLIC
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FDA: Some Asthma Drugs Riskier for Kids Than Adults Wed Oct 26, 2011 7:11 am
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