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Drug May Help Relieve Chronic Constipation Thu Aug 11, 2011 8:14 am
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Drug May Help Relieve Chronic Constipation


Aug. 10, 2011 -- Two studies show that a new kind of experimental medication relieves the pain and bloating of persistent constipation better than a placebo.

The studies, which are published in the New England Journal of Medicine, found that linoclotide relieved chronic constipation in up to 21% of patients, compared to as many as 6% who were helped on a placebo.

As many as one in five Americans suffer from chronic constipation, meaning that they have fewer than three bowel movements a week for at least three months. The condition is most common in women, the elderly, and people who suffer from irritable bowel syndrome.

There's currently one prescription drug, Amitiza, that's widely used for treating chronic constipation.

A host of other over-the-counter remedies haven't been well studied in patients for whom constipation has become a long-term problem.

Study researcher Anthony J. Lembo, MD, a gastroenterologist at Beth Israel Deaconess Medical Center in Boston, says linoclotide is unique because it stimulates cells in the lining of the bowel to produce secretions that help draw more fluid into the gut. The fluid helps to soften stool and speed its passage.

"It won't help everybody, of course. Not all patients have their symptoms relieved," Lembo tells WebMD. "There are a lot of different causes for constipation."

http://www.webmd.com/ibs/news/20110810/drug-may-help-relieve-chronic-constipation?src=RSS_PUBLIC
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Drug May Help Relieve Chronic Constipation Thu Aug 11, 2011 8:14 am
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