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57 Genes Now Linked to MS Thu Aug 11, 2011 2:33 am
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57 Genes Now Linked to MS


Aug. 10, 2011 -- The number of genes linked to multiple sclerosis (MS) is now up to 57, following a large international study of more than 9,000 people with the disease.

The genetic mapping of the disorder, a chronic disease affecting the central nervous system, is moving at a swift pace, says researcher Alastair Compston, MD, PhD, professor of neurology at the University of Cambridge, U.K.

"We have moved from three [genes linked] in 2007 to 57 now," he tells WebMD.

The new research confirms 23 genes that were suspected to be linked with MS and adds another 34, he says. Of that 34, 29 are definite and five are probable. The new findings also provide support for the belief that MS begins with an abnormal response of the body's immune system, he says.

"If we look at the genes which are implicated by these 57 hits, they tell a remarkably coherent story, because 80% of them are all genes which drive the body's immune response,” Compston says. “They are immunological genes."

Experts have debated whether MS is a degenerative disease that triggers immune system inflammation or whether the process is the reverse. "Based on this research, the inflammation comes first," Compston says.

For MS patients, he tells WebMD, the findings suggest that treatments that do not focus on immunological origins don't make much sense.

The research is published in Nature.

http://www.webmd.com/multiple-sclerosis/news/20110810/genes-linked-to-ms-now-number-57?src=RSS_PUBLIC
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57 Genes Now Linked to MS Thu Aug 11, 2011 2:33 am
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